COVID-19 research in Wales

COVID-19 research in Wales

The following Coronavirus COVID-19 related research studies are active or are in set up in Wales: 

 

Open and recruiting – Urgent Public Health (UPH) studies

 

Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial

The Randomised Evaluation of COVID Therapy (RECOVERY) trial will test if existing or new drugs can help patients hospitalised with confirmed COVID-19.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board, Hywel Dda University Health Board, Swansea Bay University Health Board, Velindre University NHS Trust


COVID-19: ISARIC - Coronavirus Clinical Characterisation Consortium (ISARIC-4C) / CCP-UK Clinical Characterisation Protocol for Severe Emerging Infection

The researchers will collect samples and data from COVID-19 patients in the UK to answer many urgent questions about the virus in real time.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board, Hywel Dda University Health Board, Swansea Bay University Health Board


REMAP-CAP: a platform trial for severely ill patients with COVID-19

A randomised controlled trial for patients admitted to the intensive care unit (ICU) with severe Community-Acquired Pneumonia (CAP). This trial studies a number of different treatment categories under one platform with an aim to determine the best package of treatment for patients.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board, Swansea Bay University Health Board


UK Obstetric Surveillance System (UKOSS)

Maternal and Perinatal Outcomes of Pandemic Influenza in Pregnancy.

Open in: all Health Boards in Wales


Evaluation and refinement of pandemic influenza community assessment tools (FLU-CATs)

Real time refinement and validation of criteria and tools used in primary care to aid hospital referral decisions for patients of all ages in the event of surge during an influenza pandemic.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cwm Taf Morgannwg University Health Board, Hywel Dda University Health Board, Powys Teaching Health Board, Swansea Bay University Health Board


Genetics of susceptibility and mortality in critical care (GenOMICC)

Our genes determine how susceptible we are to life-threatening infection. When a patient is already sick, different genetic factors determine how likely they are to survive. The GenOMICC (Genetics of Susceptibility and Mortality in Critical Care) study will identify the specific genes that cause some people to be susceptible to specific infections and consequences of severe injury.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board, Hywel Dda University Health Board, Swansea Bay University Health Board


RECOVERY - Respiratory Support

This study is aiming to determine if continuous positive airway pressure (CPAP) or high flow nasal oxygen (HFNO) is clinically effective compared to standard care (excluding CPAP or HFNO).

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board


Neonatal Complications of Coronavirus Disease (COVID-19) Study

This is a national surveillance programme using the standard British Paediatric Surveillance Unit (BPSU) approach. This study will run alongside and be cross-linked with the maternal surveillance study run through the United Kingdom Obstetric Surveillance System (UKOSS; CPMS: 14162), which is already in progress.

Open in: all Health Boards in Wales


Pregnancy and Neonatal Outcomes in COVID-19

To better understand some specific research questions as to how COVID-19 affects early pregnancy, fetal growth, prematurity and virus transmission to the baby the researchers will construct a registry of women with suspected and confirmed COVID-19.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board, Swansea Bay University Health Board


Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE)

The trial aims to give a rapid answer about the effectiveness of hydroxychloroquine in modifying the disease course of COVID-19.

Open: Wales wide


Phase 3 multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of canakinumab on cytokine release syndrome in patients with COVID-19-induced pneumonia (CAN-COVID)

Open in: Cardiff and Vale University Health Board


Multiarm Therapeutic study in pre-ICU patients admitted with COVID-19 - Repurposed Drugs (TACTIC-R)

TACTIC is recruiting patients at an early stage of COVID-19 disease course, aiming for a time point where the patient is experiencing infective symptoms and starting to show pulmonary complications. The purpose is to prevent organ damage and reduce the need to transfer to ICU and ventilation. The aim of this trial is to reduce the number of COVID-19 patients that will be admitted to ICU.

Open in: Cardiff and Vale University Health Board


The effectiveness and cost-effectiveness of a group programme for men who are concerned about their abusive behaviour in relationships with women: A randomised controlled trial (REPROVIDE)

This study has been open to recruitment since October 2019, and forms part of an NIHR programme grant called 'Reaching Everyone: Programme of Research on Violence in Diverse Domestic Environments' (REPROVIDE). It has been repurposed in light of COVID-19 as the victim support and signposting services to partners and ex-partners, and the identification and monitoring of abusive men that are provided within the context of the study are vitally important services to continue.

Open: Wales wide


CATALYST: A randomised phase II proof of principle multi-arm multi-stage trial designed to guide the selection of interventions for phase III trials in hospitalised patients with COVID-19 infection

This is a clinical trial, in which participants are randomised to one of a number of potential new treatments for COVID-19.

Open: Cardiff and Vale University Health Board, Swansea Bay University Health Board


STOP-COVID19

This clinical trial is designed to evaluate the potential of Brensocatib (INS1007) as a novel host directed therapy for the treatment of adult patients hospitalized with COVID-19. 

Open: Cardiff and Vale University Health Board


CLARITY

ImpaCt of bioLogic therApy on saRs-cov-2 Infection and immuniTY

This study will provide an evidence base for safer prescribing of immunomodulator and biologic drugs in the COVID-19 era and inform public health policy regarding physical distancing measures, and future vaccination strategies. Although this study will define risk in IBD patients, there are potentially important lessons to be learned for millions of patients across the UK with other immune mediated diseases treated with similar therapies.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board, Hywel Dda University Health Board, Swansea Bay University Health Board


MERMAIDS – ARI

Multi-centre EuRopean study of MAjor Infectious Disease Syndromes: Acute Respiratory Infections in Adults

The aim of this study is to find out why some people become much more ill than others when they have acute respiratory infections. More information about how different people respond to the agents that cause respiratory disease will allow us to better predict how bad the infection is likely to be and to develop treatments specific to that particular patient. This could reduce disease severity and the risk of complications and also reduce the need for hospital admission.

Open: Aneurin Bevan University Health Board

In setup: Betsi Cadwaladr University Health Board


PHOSP-COVID

Post-hospitalisation COVID-19 study: a national consortium to understand and improve long-term health outcomes

A comprehensive patient-centred holistic study is required to determine the chronic health and health economic sequelae of COVID-19 infection in post-hospitalisation survivors. This will define demographic, clinical and molecular biomarkers of the susceptibility and inform our understanding of the impact of interventions during the acute illness. These will guide consequent in-depth studies to inform precision medicine in at risk groups by directing new clinical trials and care for current and future post-COVID-19 patients. The study will continue to link to participants clinical data for at least 25 years or until the patient has deceased or withdrawn consent.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cardiff and Vale University Health Board, Hywel Dda University Health Board, Swansea Bay University Health Board


SIREN - SARS-COV2 immunity and reinfection evaluation

The impact of detectable anti SARS-COV2 antibody on the incidence of COVID-19 in healthcare workers

The aim of this study is to find out whether healthcare workers who have evidence of prior COVID-19, detected by positive antibody tests, compared to those who do not have evidence of infection (negative antibody tests) are protected from future episodes of infection. We will recruit healthcare workers to be followed for at least a year and study their immune response to the virus causing COVID-19. We will do this by collecting data on their history of COVID-19 infection and any new symptoms. Through this study, we will provide this very important information which will help us to understand the future impact of COVID-19 on the population.

In setup: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cwm Taf Morgannwg University Health Board, Velindre University NHS Trust


Virus Watch

Understanding community incidence, symptom profiles, and transmission of COVID-19 in relation to population movement and behaviour.

Virus Watch is UK's largest and most comprehensive household community study of its kind. This study will follow up over 40,000 participants. This study will follow up over 40,000 members of the public all over England and Wales using regular online surveys of symptoms and behaviour as well as an optional secure movement tracking app. A group of 10,000 participants, will be tested for COVID-19 infection and subsequent immunity. The information will be used to build a detailed picture of how the virus spreads and how the public behave. The information will be shared with participants, health service and public health planners and the general public to help minimise the impact of the virus.

Open in: Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board, Hywel Dda University Health Board, Swansea Bay University Health Board


COVID-HEART

Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID 19: a UK national study (The COVID-HEART Study)

Up to 1 in 5 patients hospitalised by COVID-19 have evidence of heart muscle injury as measured from a blood test. This is associated with a high death rate. Using a magnetic resonance imaging (MRI) scan (a type of scan that uses strong magnetic fields and radio waves to produce detailed images of the inside of the heart) we will look at how often, and in what way, the heart becomes damaged, and how the heart recovered 6 months later.

Open in: Swansea Bay University Health Board